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Search Results for " thymidylate kinase "

Targets

12

Compounds

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T8864 Thymidylate Kinase Inhibitor, YMU1 Others
YMU1 is a human thymidylate kinase (hTMPK) inhibitor. YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site.
T61781 MtTMPK-IN-6
MtTMPK-IN-6 (compound 1) is a highly effective inhibitor (IC 50 = 29 μM) of M. tuberculosis thymidylate kinase (Mtb TMPK). It is a valuable compound for tuberculosis research [1].
T61780 MtTMPK-IN-4
MtTMPK-IN-4 (compound 2), a para-piperidine, is a highly potent inhibitor of thymidylate kinase (MtTMPK) in Mycobacterium tuberculosis, exhibiting an IC50 value of 6.1 μM. Additionally, it possesses remarkable inhibitory...
T61796 MtTMPK-IN-1
MtTMPK-IN-1 (compound 3) is a highly effective inhibitor of Mycobacterium tuberculosis thymidylate kinase (Mt TMPK), exhibiting an IC50 value of 2.5 μM. It displays moderate to weak activity against Mtb H37Rv while demon...
T35652 2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. In addition, dGMP can be effi...
T61573 MtTMPK-IN-5
MtTMPK-IN-5 (compound 17) is a highly effective inhibitor of M. tuberculosis thymidylate kinase (Mtb TMPK), demonstrating remarkable enzyme inhibitory activity with an IC50 value of 34 μM. Additionally, MtTMPK-IN-5 exhib...
T63657 MtTMPK-IN-9
MtTMPK-IN-9 is a moderately potent inhibitor of Mycobacterium thymidylate kinase (MtbTMPK) (IC50: 48 μM).MtTMPK-IN-9 has submicromolar activity against Mycobacterium but no significant cytotoxicity.MtTMPK-IN-9 can be use...
T63491 MtTMPK-IN-8
MtTMPK-IN-8 is a moderately potent inhibitor of Mycobacterium thymidylate kinase (MtbTMPK) with no significant cytotoxicity, exhibiting submicromolar activity (MICs = 0.78-9.4 μM) against Mycobacterium and capable of bei...
T63639 MtTMPK-IN-7
MtTMPK-IN-7 is a moderately potent inhibitor of Mycobacterium brevis thymidylate kinase (MtbTMPK) (IC50: 47 μM).MtTMPK-IN-7 exhibits submicromolar activity against Mycobacterium brevis with MICs ranging from 2.3 to 4.7 μ...
T73980 Thymidine 5′-diphosphate
Thymidine 5′-diphosphate (dTDP), a crucial product of pyrimidine synthesis in organisms, is synthesized through the thymidylate kinase (TMPK)-catalyzed phosphorylation of 5′-thymidine monophosphate (dTMP), requiring ATP ...
T62305 MtTMPK-IN-2
MtTMPK-IN-2 (compound 15), a potent inhibitor of Mycobacterium tuberculosis thymidylate kinase (Mt TMPK), demonstrates an IC50 value of 1.1 μM. This compound effectively inhibits Mtb H37Rv with a minimum inhibitory conce...
T62897 MtTMPK-IN-3
MtTMPK-IN-3 (compound 25) is a potent inhibitor of Mycobacterium tuberculosis thymidylate kinase (MtTMPK) with an IC50 value of 0.12 μM. It also demonstrates inhibitory activity against Mtb H37Rv with a MIC of 12.5 μM an...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-00157 Thymidylate kinase Protein, Bacillus anthracis, Recombinant (His) Bacillus anthracis E. coli
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. Thymidylate kinase Protein, Bacillus anthracis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. T...
TMPJ-00905 DTYMK Protein, Human, Recombinant (His) Human HEK293 Cells
Thymidylate kinase (DTYMK) is a ubiquitous enzyme of about 25 kD which belongs to thymidylate kinase family. DTYMK is important in the dTTP synthesis pathway for DNA synthesis. It participated in the pyrimidine metabolis...
TargetMol